Which LIU type results from leakage of lens proteins through the capsule?

Which LIU type results from leakage of lens proteins through the capsule?

• A. Phacoclastic uveitis
• B. Phacolytic uveitis
• C. Irisitis
• D. Endophthalmitis

Answer: (B)

Leakage of lens proteins through the capsule triggers phacolytic uveitis. In a degenerated or hypermature lens, the capsule becomes porous, allowing soluble lens proteins to seep into the anterior chamber. These proteins act as antigens, provoking a macrophage‑mediated inflammatory response in the anterior uvea. Clinically this presents as acute or subacute anterior uveitis with signs of protein in the aqueous and sometimes milky material in the chamber, but without an infectious process. This is different from phacoclastic uveitis, where the capsule ruptures and whole lens contents spill into the chamber, causing a more intense reaction. Irisitis is inflammation of the iris itself from various causes, not specifically due to lens protein leakage, and endophthalmitis is an intraocular infection.

Leakage of lens proteins through the capsule triggers phacolytic uveitis. In a degenerated or hypermature lens, the capsule becomes porous, allowing soluble lens proteins to seep into the anterior chamber. These proteins act as antigens, provoking a macrophage‑mediated inflammatory response in the anterior uvea. Clinically this presents as acute or subacute anterior uveitis with signs of protein in the aqueous and sometimes milky material in the chamber, but without an infectious process. This is different from phacoclastic uveitis, where the capsule ruptures and whole lens contents spill into the chamber, causing a more intense reaction. Irisitis is inflammation of the iris itself from various causes, not specifically due to lens protein leakage, and endophthalmitis is an intraocular infection.