Which cataract stage is characterized by capsular wrinkling and protein aggregates?

Which cataract stage is characterized by capsular wrinkling and protein aggregates?

• A. Hypermature cataract (correct)
• B. Incipient cataract
• C. Immature cataract
• D. Mature cataract

Answer: (A)

Capsular wrinkling with protein aggregates is a hallmark of a hypermature cataract. In this advanced stage the cortex has largely liquefied and the lens loses support, causing the capsule to contract and develop wrinkles. At the same time, denatured proteins can precipitate and form aggregates, contributing to the dense opacification. Earlier stages don’t show this combination. An incipient cataract presents with only fine, minute opacities and a largely normal capsule. An immature cataract has partial opacification with some preserved clarity. A mature cataract is fully opaque, but without the pronounced cortical liquefaction and capsule wrinkling seen in the hypermature stage.

Capsular wrinkling with protein aggregates is a hallmark of a hypermature cataract. In this advanced stage the cortex has largely liquefied and the lens loses support, causing the capsule to contract and develop wrinkles. At the same time, denatured proteins can precipitate and form aggregates, contributing to the dense opacification.

Earlier stages don’t show this combination. An incipient cataract presents with only fine, minute opacities and a largely normal capsule. An immature cataract has partial opacification with some preserved clarity. A mature cataract is fully opaque, but without the pronounced cortical liquefaction and capsule wrinkling seen in the hypermature stage.