What is the most common cause of primary lens luxation?

What is the most common cause of primary lens luxation?

• A. Genetic zonular degeneration
• B. Traumatic zonular rupture
• C. Age-related zonular laxity
• D. Uveitis-related zonular weakness

Answer: (A)

Primary lens luxation happens when the lens-supporting zonules are inherently weak due to genetic or connective tissue defects. That intrinsic zonular degeneration is the most common cause because it arises from the structure of the eye itself, not from an outside event. Classic examples are inherited conditions such as Marfan syndrome and homocystinuria, where mutations affect zonular fibers and make the lens prone to subluxation or dislocation without trauma. Traumatic zonular rupture would be an acquired, secondary cause; age-related laxity and uveitis-related weakness can contribute but are not the primary, inherited basis of luxation.

Primary lens luxation happens when the lens-supporting zonules are inherently weak due to genetic or connective tissue defects. That intrinsic zonular degeneration is the most common cause because it arises from the structure of the eye itself, not from an outside event. Classic examples are inherited conditions such as Marfan syndrome and homocystinuria, where mutations affect zonular fibers and make the lens prone to subluxation or dislocation without trauma. Traumatic zonular rupture would be an acquired, secondary cause; age-related laxity and uveitis-related weakness can contribute but are not the primary, inherited basis of luxation.